Toplam 99 içerik listeleniyor
-
A new genome editing method brings the possibility of gene therapies closer to reality
Researchers from Salk Institute for Biological Studies, BGI, and other institutes for the first time evaluated the safety and reliability of the existing targeted gene correction technologies, and successfully developed a new method, TALEN-HDAdV, which could significantly increased gene-correction efficiency in human induced pluripotent stem cell (hiPSC). This study published online in Cell Stell Cell provides an important theoretical foundation for stem cell-based gene...
https://www.biyologlar.com/a-new-genome-editing-method-brings-the-possibility-of-gene-therapies-closer-to-reality-haber-8766 -
CAR T-Hücrelerinin Güvenliğini Arttırmak için Yeni Fikirler
Romatoid artritin tedavisi için onaylanan ilaçlar, immünoterapiden kaynaklanan ciddi yan etkilerden sorumlu moleküller olan sitokinleri bloke ediyor ve farelerde semptomları azaltıyor.
https://www.biyologlar.com/car-t-hucrelerinin-guvenligini-arttirmak-icin-yeni-fikirler -
CAR T-Hücrelerinin Güvenliğini Arttırmak için Yeni Fikirler
Romatoid artritin tedavisi için onaylanan ilaçlar, immünoterapiden kaynaklanan ciddi yan etkilerden sorumlu moleküller olan sitokinleri bloke ediyor ve farelerde semptomları azaltıyor.
https://www.biyologlar.com/car-t-hucrelerinin-guvenligini-arttirmak-icin-yeni-fikirler -
KÖK HÜCRELERE BAKIŞ:TANIMLAR, KAVRAMLAR ve SINIFLANDIRMALAR
İki binli yıllarla beraber kök hücrelerin rejeneratif tıp (yenileyici tıp) alanındaki öneminin giderek arttığını ve tıbbın geleceğini şekillendirme potansiyelini gözlemlemekteyiz.
https://www.biyologlar.com/kok-hucrelere-bakistanimlar-kavramlar-ve-siniflandirmalar -
RNA from Trained Aplysia Can Induce an Epigenetic Engram for Long-Term Sensitization in Untrained Aplysia.
Abstract The precise nature of the engram, the physical substrate of memory, remains uncertain. Here, it is reported that RNA extracted from the central nervous system of Aplysia given long-term sensitization training induced sensitization when injected into untrained animals; furthermore, the RNA-induced sensitization, like training-induced sensitization, required DNA methylation. In cellular experiments, treatment with RNA extracted from trained animals was found to increase excitability...
https://www.biyologlar.com/rna-from-trained-aplysia-can-induce-an-epigenetic-engram-for-long-term-sensitization-in-untrained-aplysia- -
RNA from Trained Aplysia Can Induce an Epigenetic Engram for Long-Term Sensitization in Untrained Aplysia.
Abstract The precise nature of the engram, the physical substrate of memory, remains uncertain. Here, it is reported that RNA extracted from the central nervous system of Aplysia given long-term sensitization training induced sensitization when injected into untrained animals; furthermore, the RNA-induced sensitization, like training-induced sensitization, required DNA methylation. In cellular experiments, treatment with RNA extracted from trained animals was found to increase excitability...
https://www.biyologlar.com/rna-from-trained-aplysia-can-induce-an-epigenetic-engram-for-long-term-sensitization-in-untrained-aplysia- -
New stem cells go back further
One of the obstacles to employing human embryonic stem cells for medical use lies in their very promise: They are born to rapidly differentiate into other cell types.
https://www.biyologlar.com/new-stem-cells-go-back-further -
Researchers use human stem cells to create light-sensitive retina in a dish
Using a type of human stem cell, Johns Hopkins researchers say they have created a three-dimensional complement of human retinal tissue in the laboratory, which notably includes functioning photoreceptor cells capable of responding to light, the first step in the process of converting it into visual images.
https://www.biyologlar.com/researchers-use-human-stem-cells-to-create-light-sensitive-retina-in-a-dish -
Brain's on-off thirst switch identified
NEW YORK, NY (January 26, 2015)--Neurons that trigger our sense of thirst--and neurons that turn it off--have been identified by Columbia University Medical Center neuroscientists. The paper was published today in the online edition of Nature. For years, researchers have suspected that thirst is regulated by neurons in the subfornical organ (SFO), in the hypothalamus. But it has been difficult to pinpoint exactly which neurons are involved. "When researchers used electrical current to...
https://www.biyologlar.com/brains-on-off-thirst-switch-identified -
Wisconsin scientists find genetic recipe to turn stem cells to blood
The ability to reliably and safely make in the laboratory all of the different types of cells in human blood is one key step closer to reality.
https://www.biyologlar.com/wisconsin-scientists-find-genetic-recipe-to-turn-stem-cells-to-blood -
Scientists create functional liver cells from stem cells
The liver plays a critical role in human metabolism. As the gatekeeper of the digestive track, this massive organ is responsible for drug breakdown and is therefore the first to be injured due to overdose or misuse. Evaluating this drug-induced liver injury is a critical part of pharmaceutical drug discovery and must be carried out on human liver cells. Regretfully, human liver cells, called hepatocytes, are in scarce supply as they can only be isolated from donated organs. Now, in research...
https://www.biyologlar.com/scientists-create-functional-liver-cells-from-stem-cells -
Restoring vision with stem cells
Age-related macular degeneration (AMRD) could be treated by transplanting photoreceptors produced by the directed differentiation of stem cells, thanks to findings published today by Professor Gilbert Bernier of the University of Montreal and its affiliated Maisonneuve-Rosemont Hospital. ARMD is a common eye problem caused by the loss of cones. Bernier's team has developed a highly effective in vitro technique for producing light sensitive retina cells from human embryonic stem cells. "Our...
https://www.biyologlar.com/restoring-vision-with-stem-cells -
Are embryonic stem cells and artificial stem cells equivalent?
Harvard Stem Cell Institute (HSCI) researchers at Massachusetts General Hospital and Harvard Medical School have found new evidence suggesting some human induced pluripotent stem cells are the 'functional equivalent' of human embryonic stem cells, a finding that may begin to settle a long running argument. The findings were published this week in Nature Biotechnology. From 1998 until 2007 embryonic stem cells (ES cells) were the only human cells known with the potential to become any other...
https://www.biyologlar.com/are-embryonic-stem-cells-and-artificial-stem-cells-equivalent -
An alternative TALEN/CRISPR-mediated gene insertion technique described in detail
A streamlined protocol for an alternative gene insertion method using genome editing technologies, the PITCh (Precise Integration into Target Chromosome) system, has been reported in Nature Protocols by Specially Appointed Lecturer Tetsushi Sakuma, Professor Takashi Yamamoto, Specially Appointed Associate Professor Ken-Ichi T Suzuki, and their colleagues at Hiroshima University, Japan. The PITCh system is more convenient and effective than existing methods for inserting foreign DNA into...
https://www.biyologlar.com/an-alternative-talencrispr-mediated-gene-insertion-technique-described-in-detail -
An alternative TALEN/CRISPR-mediated gene insertion technique described in detail
A streamlined protocol for an alternative gene insertion method using genome editing technologies, the PITCh (Precise Integration into Target Chromosome) system, has been reported in Nature Protocols by Specially Appointed Lecturer Tetsushi Sakuma, Professor Takashi Yamamoto, Specially Appointed Associate Professor Ken-Ichi T Suzuki, and their colleagues at Hiroshima University, Japan. The PITCh system is more convenient and effective than existing methods for inserting foreign DNA into...
https://www.biyologlar.com/an-alternative-talencrispr-mediated-gene-insertion-technique-described-in-detail -
Oncogene controls stem cells in early embryonic development
After a gestation period of around ten months, fawns are born in early summer - when the weather is warm and food is plentiful for the mother. Six months would actually be enough for the embryo's development, but then offspring from mating in the later portion of summer would be born in winter. Therefore, nature prolongs the gestation period by a hormone-regulated pause in the development of the early embryos. Many animal species use this process, called diapause, to adjust their reproduction...
https://www.biyologlar.com/oncogene-controls-stem-cells-in-early-embryonic-development -
Researchers use single molecule of DNA to create world's smallest diode
Researchers at the University of Georgia and at Ben-Gurion University in Israel have demonstrated for the first time that nanoscale electronic components can be made from single DNA molecules. Their study, published in the journal Nature Chemistry, represents a promising advance in the search for a replacement for the silicon chip. The finding may eventually lead to smaller, more powerful and more advanced electronic devices, according to the study's lead author, Bingqian Xu. "For 50 years,...
https://www.biyologlar.com/researchers-use-single-molecule-of-dna-to-create-worlds-smallest-diode -
Researchers use single molecule of DNA to create world's smallest diode
Researchers at the University of Georgia and at Ben-Gurion University in Israel have demonstrated for the first time that nanoscale electronic components can be made from single DNA molecules. Their study, published in the journal Nature Chemistry, represents a promising advance in the search for a replacement for the silicon chip. The finding may eventually lead to smaller, more powerful and more advanced electronic devices, according to the study's lead author, Bingqian Xu. "For 50 years,...
https://www.biyologlar.com/researchers-use-single-molecule-of-dna-to-create-worlds-smallest-diode -
Mantis shrimp inspires next generation of ultra-strong materials
This is the herringbone structure of the outer layer (impact region) of the mantis shrimp dactyl club.
https://www.biyologlar.com/mantis-shrimp-inspires-next-generation-of-ultra-strong-materials -
Mantis shrimp inspires next generation of ultra-strong materials
This is the herringbone structure of the outer layer (impact region) of the mantis shrimp dactyl club.
https://www.biyologlar.com/mantis-shrimp-inspires-next-generation-of-ultra-strong-materials -
DNA damage by ultrashort pulses of intense laser light
DNA damage caused by very low-energy electrons and OH-radicals formed upon irradiation of water by ultrashort pulses of very intense laser light.
https://www.biyologlar.com/dna-damage-by-ultrashort-pulses-of-intense-laser-light -
DNA damage by ultrashort pulses of intense laser light
DNA damage caused by very low-energy electrons and OH-radicals formed upon irradiation of water by ultrashort pulses of very intense laser light.
https://www.biyologlar.com/dna-damage-by-ultrashort-pulses-of-intense-laser-light -
New procedure allows long-term culturing of adult stem cells
A new procedure developed at Massachusetts General Hospital (MGH) may revolutionize the culturing of adult stem cells. In their report that has been published online prior to its appearance in the August 6 issue of Cell Stem Cell, the team describes generating and expanding airway stem cells from the sorts of tissue samples collected during routine treatment of lung disorders. The overall approach appears applicable to several other tissue types, including skin and the linings of the...
https://www.biyologlar.com/new-procedure-allows-long-term-culturing-of-adult-stem-cells -
How a single molecule turns one immune cell into another
All it takes is one molecule to reprogram an antibody-producing B cell into a scavenging macrophage. This transformation is possible, new evidence shows, because the molecule (C/EBPa, a transcription factor) "short-circuits" the cells so that they re-express genes reserved for embryonic development. The findings appear July 30 in Stem Cell Reports, the journal of the International Society for Stem Cell Research. Over the past 28 years, researchers have shown that a number of specialized cell...
https://www.biyologlar.com/how-a-single-molecule-turns-one-immune-cell-into-another -
Purest yet liver-like cells generated from induced pluripotent stem cells
This image shows induced pluripotent stem cells expressing a characteristic cell surface protein called SSEA4 (green).
https://www.biyologlar.com/purest-yet-liver-like-cells-generated-from-induced-pluripotent-stem-cells -
Purest yet liver-like cells generated from induced pluripotent stem cells
This image shows induced pluripotent stem cells expressing a characteristic cell surface protein called SSEA4 (green).
https://www.biyologlar.com/purest-yet-liver-like-cells-generated-from-induced-pluripotent-stem-cells -
First gene linked to temperature sex switch
The sex of many reptile species is set by temperature. New research reported in the journal GENETICS identifies the first gene associated with temperature-dependent sex determination in any reptile.
https://www.biyologlar.com/first-gene-linked-to-temperature-sex-switch -
First gene linked to temperature sex switch
The sex of many reptile species is set by temperature. New research reported in the journal GENETICS identifies the first gene associated with temperature-dependent sex determination in any reptile.
https://www.biyologlar.com/first-gene-linked-to-temperature-sex-switch -
Hydra can modify its genetic program
Champion of regeneration, the freshwater polyp Hydra is capable of reforming a complete individual from any fragment of its body. It is even able to remain alive when all its neurons have disappeared. Researcher the University of Geneva (UNIGE), Switzerland, have discovered how: cells of the epithelial type modify their genetic program by overexpressing a series of genes, among which some are involved in diverse nervous functions. Studying Hydra cellular plasticity may thus influence research...
https://www.biyologlar.com/hydra-can-modify-its-genetic-program -
Hydra can modify its genetic program
Champion of regeneration, the freshwater polyp Hydra is capable of reforming a complete individual from any fragment of its body. It is even able to remain alive when all its neurons have disappeared. Researcher the University of Geneva (UNIGE), Switzerland, have discovered how: cells of the epithelial type modify their genetic program by overexpressing a series of genes, among which some are involved in diverse nervous functions. Studying Hydra cellular plasticity may thus influence research...
https://www.biyologlar.com/hydra-can-modify-its-genetic-program -
Biologists find genetic mechanism for 'extremophile' fish survival
A Washington State University biologist has found the genetic mechanisms that lets a fish live in toxic, acidic water. The discovery opens the door to new insights into the functioning of other "extremophiles" and how they adapt to their challenging environments. "These fish are very extreme," said Joanna Kelley, a genome scientist in the School of Biological Sciences at Washington State University. "Ordinary fish, when you put them in that water, are belly up in about a minute." Kelley and...
https://www.biyologlar.com/biologists-find-genetic-mechanism-for-extremophile-fish-survival -
Shape-shifting molecule tricks viruses into mutating themselves to death
A newly developed spectroscopy method is helping to clarify the poorly understood molecular process by which an anti-HIV drug induces lethal mutations in the virus's genetic material. The findings from the University of Chicago and the Massachusetts Institute of Technology could bolster efforts to develop the next generation of anti-viral treatments. Viruses can mutate rapidly in order to adapt to environmental pressure. This feature also helps them become resistant to anti-viral drugs. But...
https://www.biyologlar.com/shape-shifting-molecule-tricks-viruses-into-mutating-themselves-to-death -
Cell death: How a protein drives immune cells to suicide
The best hiding place often lies behind enemy lines, as many bacteria such as the pathogens responsible for tuberculosis or typhoid have realized. They invade immune cells and can survive there, well hidden, for some time. To eliminate such invaders, the host macrophages can initiate a suicide program. Together with researchers at the Novartis Institute for Biomedical Research and ETH Zurich, the team led by Prof. Sebastian Hiller from the Biozentrum at the University of Basel has shown for the...
https://www.biyologlar.com/cell-death-how-a-protein-drives-immune-cells-to-suicide -
Cell death: How a protein drives immune cells to suicide
The best hiding place often lies behind enemy lines, as many bacteria such as the pathogens responsible for tuberculosis or typhoid have realized. They invade immune cells and can survive there, well hidden, for some time. To eliminate such invaders, the host macrophages can initiate a suicide program. Together with researchers at the Novartis Institute for Biomedical Research and ETH Zurich, the team led by Prof. Sebastian Hiller from the Biozentrum at the University of Basel has shown for the...
https://www.biyologlar.com/cell-death-how-a-protein-drives-immune-cells-to-suicide -
Fetal mice with Zika infection get microcephaly
Mouse fetuses injected with the Asian Zika virus strain and carried to term within their pregnant mothers display the characteristic features of microcephaly, researchers in China report May 11 in Cell Stem Cell. As expected, the virus infected the neural progenitor cells, and infected brains reveal expression of genes related to viral entry, altered immune response, and cell death. The authors say this is direct evidence that Zika infection causes microcephaly in a mammalian animal...
https://www.biyologlar.com/fetal-mice-with-zika-infection-get-microcephaly -
Fetal mice with Zika infection get microcephaly
Mouse fetuses injected with the Asian Zika virus strain and carried to term within their pregnant mothers display the characteristic features of microcephaly, researchers in China report May 11 in Cell Stem Cell. As expected, the virus infected the neural progenitor cells, and infected brains reveal expression of genes related to viral entry, altered immune response, and cell death. The authors say this is direct evidence that Zika infection causes microcephaly in a mammalian animal...
https://www.biyologlar.com/fetal-mice-with-zika-infection-get-microcephaly -
Penn study reveals how fish control microbes through their gills
Oriol Sunyer, a professor at the University of Pennsylvania School of Veterinary Medicine, has described fish as "an open gut swimming."
https://www.biyologlar.com/penn-study-reveals-how-fish-control-microbes-through-their-gills -
Human kidney progenitors isolated, offering new clues to cell renewal
In a first-of-its-kind look at human kidney development, researchers at The Saban Research Institute of Children's Hospital Los Angeles have isolated human nephron progenitor (NP) cells.
https://www.biyologlar.com/human-kidney-progenitors-isolated-offering-new-clues-to-cell-renewal -
Watching a forest breathe
Flux towers are equipped with inlets for "sniffing the air " above the forest, in addition to other instruments such as sonic anemometers for measuring wind
https://www.biyologlar.com/watching-a-forest-breathe -
Watching a forest breathe
Flux towers are equipped with inlets for "sniffing the air " above the forest, in addition to other instruments such as sonic anemometers for measuring wind
https://www.biyologlar.com/watching-a-forest-breathe -
Discovery of new hepatitis C virus mechanism
SPP inhibition reduces production of infectious HCV particles and pathogenesis,
https://www.biyologlar.com/discovery-of-new-hepatitis-c-virus-mechanism -
Discovery of new hepatitis C virus mechanism
SPP inhibition reduces production of infectious HCV particles and pathogenesis,
https://www.biyologlar.com/discovery-of-new-hepatitis-c-virus-mechanism -
İndüklenmiş pluripotent kök hücreler
İnsan iPSC'lerinin hücre akıbetini kontrol etmek için kullanılan geniş bir hücre kültürü ortamı koleksiyonu, takviyeleri, biyoaktif küçük moleküller ve büyüme faktörleri sunuyoruz. Aşağıdaki tablo, insan iPSC'lerini farklı hücre soylarına ayırmak için kullanılan en yaygın şekilde kullanılan protokolleri, ortamları ve karakterizasyon antikorlarını vurgulamaktadır.
https://www.biyologlar.com/pluripotent-ozellik-nedir -
Apoptozis ve kaspazlar
Apoptozis, organizma tarafından düzenlenen enerji bağımlı hücre ölümüdür. Programlı hücre ölümü olarak da adlandırılan bu süreç, doku homeostazının korunmasında kritik bir role sahip olduğu gibi, fetal gelişim ve erişkin dokulardaki pekçok fizyolojik olayda da önemli rollere sahiptir. Apoptozis terimi ilk kez 1972 yılında Kerr ve arkadaşları tarafından kullanılmıştır (1). Kerr, fizyolojik olarak ölen hücrelerin çekirdeklerinde yoğunlaşmış kromatin...
https://www.biyologlar.com/apoptozis-ve-kaspazlar -
Kanser tedavisinde immün yanıtı tetikleyen yeni bir aşı!
Gene Therapy dergisinin yeni sayısında yayımlanan bir araştırmaya göre, hücreler ve vücudun bağışıklık sistemi arasındaki iletişimden sorumlu belirli bir protein ve reseptör üreten tümörleri hedefleyen bir aşının, kanserle savaşmak için immün yanıtı başlatabileceği ileri sürüldü. Son yıllarda çok sayıda antitümör aşısı, tedavi başarısını iyileştirmek için, tümör antijenlerine karşı immün yanıta neden olmada umut vaat ediyor.Cincinnati Kanser...
https://www.biyologlar.com/kanser-tedavisinde-immun-yaniti-tetikleyen-yeni-bir-asi -
Hamilelikte parasetamol kullanımı erkek bebekte kısırlığa neden oluyor!
Gebelikte kadınların uzun süre parasetamol maddesi içeren ağrı kesiciler kullanmasının erkek bebeklerde kısırlık riskini artırabileceği ileri sürüldü. Science Translational Medicine Dergisinde yayımlanan ve farelerde yapılan araştırmanın sonuçlarına göre, hamilelerde uzun süreli parasetamol kullanımının, erkek çocukların üreme sağlığını olumsuz etkiliyor. Edinburgh Üniversitesi’nde yapılan araştırmada parasetamolün yedi gün üst üste verilmesinin...
https://www.biyologlar.com/hamilelikte-parasetamol-kullanimi-erkek-bebekte-kisirliga-neden-oluyor -
LEVREK (Dicentrarchus labrax Lin., 1758) BALIĞININ BİYOLOJİSİ VE YETİŞTİRME TEKNİKLERİ
Yrd.Dç.Dr. Kürşat FIRAT & Şahin SAKA Ege Üniversitesi Su Ürünleri Fakültesi Yetiştiricilik BölümüYetiştiricilik Anabilim Dalı İskele-Urla, 35440 İZMİR GİRİŞ Su ürünleri yetiştirme teknolojisinin gelişimi ile beraber levrek kültürü üzerindeki çalışmalarda yoğunlaşmıştır. Ülkemizde önceleri çipura balığının besiye alınması ve daha sonrada larva üretimine geçilmesini takiben, levrek larvalarının kültür çalışmalarında yoğun artışlar...
https://www.biyologlar.com/levrek-dicentrarchus-labrax-lin-1758-baliginin-biyolojisi-ve-yetistirme-teknikleri -
APUD HÜCRELERDE AMİNLERİN GÖSTERİLME YÖNTEMLERİ
Dokulardaki biyolojik aminlerin gösterilebilmelerinin temeli, aminlerin aldehit-lerle ve bazı asitlerle birleşerek spesifik floresans yayan ve spektrum yayan bileşik-leri üzerine gözlemlere dayanmaktadır. Bu bileşiklerden bazıları aynı zamanda indirge¬yici ajandır. Çoğu biyolojik amin, bulundukları hücreden hızla yayılırlar, bu yüzden aminleri hücre içinde gösterebilmek için freeze drying ve vapour fiksasvon teknikleri uygulanmalıdır; birçok aminler için (örnek...
https://www.biyologlar.com/apud-hucrelerde-aminlerin-gosterilme-yontemleri -
Kapalı iç ortamlarda maruz kalınan toksik maddeler
Üzerinde yaşadığımız gezegeni yaşanamaz hale getirmek için elimizden geleni ardımıza koymuyoruz. Daha fazla kar için her şeyin sentetiğine yönelerek doğal ürünlerden uzaklaşmak, üzerinde yaşadığımız dünyayı geleceğimizin umutları çocuklarımız için daha da yaşanmaz duruma getirmektedir. Bugün, 1940’larda olmayan/bilinmeyen, yaklaşık 80.000 sentetik kimyasal madde dünyada bulunmakta/kullanılmaktadır. Her yıl 1.500 kadar yani kimyasal madde piyasaya...
https://www.biyologlar.com/kapali-ic-ortamlarda-maruz-kalinan-toksik-maddeler -
GENEL BİYOLOJİ LABORATUAR RAPOR HAZIRLAMA FORMATI
Raporun ismi (Raporun ismi çok uzun olmamalı ve laboratuarı kısaca özetler nitelikte olmalı. İyi bir isim, içinde çalışılan konu ile ilgili anahtar kelimeleri barındıran isimdir.) Raporu hazırlayanın ismi (Raporu hazırlayan kişinin ismi Adı ve Soyadı açık olacak şekilde yazılmalı, kısaltma kullanılmamalıdır. Numara tam yazılmalı varsa email adresi eklenmelidir). Özet (Bir özetin amacı, okuyucunun raporun tamamını okumasının kendisine bir yararı olup...
https://www.biyologlar.com/genel-biyoloji-laboratuar-rapor-hazirlama-formati