Toplam 163 içerik listeleniyor
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Cells are crawling all over our bodies, but how?
For better and for worse, human health depends on a cell's motility –– the ability to crawl from place to place. In every human body, millions of cells –are crawling around doing mostly good deeds ––– though if any of those crawlers are cancerous, watch out.
https://www.biyologlar.com/cells-are-crawling-all-over-our-bodies-but-how -
Cell stress inflames the gut
Over 3.5 million people in Europe and the US suffer from Crohn's disease or ulcerative colitis – the two most common forms of IBD. Chronic bowel inflammation is caused by an overreaction of the immune system to the bacteria which naturally occur in the gut. "This overreaction can come about if, for example, the anti-stress mechanism in the cells of the intestinal mucosa does not function correctly," explains Prof. Dirk Haller of the TUM Chair of Nutrition and Immunology. What Prof. Haller is...
https://www.biyologlar.com/cell-stress-inflames-the-gut -
Stem cells + nanofibers = Promising nerve research
Every week in his clinic at the University of Michigan, neurologist Joseph Corey, M.D., Ph.D., treats patients whose nerves are dying or shrinking due to disease or injury.
https://www.biyologlar.com/stem-cells-nanofibers-promising-nerve-research -
Improving the delivery of chemotherapy with graphene
A new study published in IOP Publishing's journal 2D Materials has proposed using graphene as an alternative coating for catheters to improve the delivery of chemotherapy drugs. The research suggests that placing graphene - an extremely thin sheet of carbon atoms - on the internal surfaces of intravenous catheters commonly used to deliver chemotherapy drugs into a patient's body will improve the efficacy of treatments, and reduce the potential of the catheters breaking. The study indicates...
https://www.biyologlar.com/improving-the-delivery-of-chemotherapy-with-graphene -
Satellites show 'total' California water storage at near-decade low
Updates to satellite data show that California's Sacramento and San Joaquin River basins are at near decade-low water storage levels. These and other findings on the State's dwindling water resources were documented in an advisory report released today from the UC Center for Hydrologic Modeling (UCCHM) at the University of California, Irvine. Responding to Governor Jerry Brown's recent declaration of a drought emergency in California, a team of UCCHM researchers has updated its research on the...
https://www.biyologlar.com/satellites-show-total-california-water-storage-at-near-decade-low -
Stem-cell approach shows promise for Duchenne muscular dystrophy
Researchers have shown that transplanting stem cells derived from normal mouse blood vessels into the hearts of mice that model the pathology associated with Duchenne muscular dystrophy (DMD) prevents the decrease in heart function associated with DMD. Their findings appear in the journal Stem Cells Translational Medicine. Duchenne muscular dystrophy is a genetic disorder caused by a mutation in the gene for dystrophin, a protein that anchors muscle cells in place when they contract. Without...
https://www.biyologlar.com/stem-cell-approach-shows-promise-for-duchenne-muscular-dystrophy -
Blocking cells' movement to stop the spread of cancer
Insights into how cells move through the body could lead to innovative techniques to stop cancer cells from spreading and causing secondary tumours, according to new UCL research. Scientists discovered that cells can change into an invasive, liquid-like state to readily navigate the narrow channels in our body. This transformation is triggered by chemical signals, which could be blocked in order to stop cancer cells from spreading. Most cancer deaths are not due to primary tumours, but to...
https://www.biyologlar.com/blocking-cells-movement-to-stop-the-spread-of-cancer -
Scientists discover how 'jumping genes' help black truffles adapt to their environment
Black truffles, also known as Périgord truffles, grow in symbiosis with the roots of oak and hazelnut trees. In the world of haute cuisine, they are expensive and highly prized. In the world of epigenetics, however, the fungi (Tuber melanosporum) are of major interest for another reason: their unique pattern of DNA methylation, a biochemical process that chemically modifies nucleic acids without changing their sequence. Epigenetics is the study of changes in gene expression caused by...
https://www.biyologlar.com/scientists-discover-how-jumping-genes-help-black-truffles-adapt-to-their-environment -
Scientists reconstruct ancient impact that dwarfs dinosaur-extinction blast
Picture this: A massive asteroid almost as wide as Rhode Island and about three to five times larger than the rock thought to have wiped out the dinosaurs slams into Earth. The collision punches a crater into the planet's crust that's nearly 500 kilometers (about 300 miles) across: greater than the distance from Washington, D.C. to New York City, and up to two and a half times larger in diameter than the hole formed by the dinosaur-killing asteroid. Seismic waves bigger than any recorded...
https://www.biyologlar.com/scientists-reconstruct-ancient-impact-that-dwarfs-dinosaur-extinction-blast -
Small molecule acts as on-off switch for nature's antibiotic factory
Scientists have identified the developmental on-off switch for Streptomyces, a group of soil microbes that produce more than two-thirds of the world's naturally derived antibiotic medicines. Their hope now would be to see whether it is possible to manipulate this switch to make nature's antibiotic factory more efficient. The study, appearing August 28 in Cell, found that a unique interaction between a small molecule called cyclic-di-GMP and a larger protein called BldD ultimately controls...
https://www.biyologlar.com/small-molecule-acts-as-on-off-switch-for-natures-antibiotic-factory -
New stem cells go back further
One of the obstacles to employing human embryonic stem cells for medical use lies in their very promise: They are born to rapidly differentiate into other cell types.
https://www.biyologlar.com/new-stem-cells-go-back-further -
Enzyme controlling metastasis of breast cancer identified
Researchers at the University of California, San Diego School of Medicine have identified an enzyme that controls the spread of breast cancer. The findings, reported in the current issue of PNAS, offer hope for the leading cause of breast cancer mortality worldwide. An estimated 40,000 women in America will die of breast cancer in 2014, according to the American Cancer Society. "The take-home message of the study is that we have found a way to target breast cancer metastasis through a pathway...
https://www.biyologlar.com/enzyme-controlling-metastasis-of-breast-cancer-identified -
Firefly protein enables visualization of roots in soil
Plants form a vast network of below-ground roots that search soil for needed resources. The structure and function of this root network can be highly adapted to particular environments such as desert soils where plants like Mesquite develop tap roots capable of digging 50 meters deep to capture precious water resources. Excavation of root systems reveals these kinds of adaptations but is laborious, time consuming, and does not provide information on how growing roots behave. A new imaging tool...
https://www.biyologlar.com/firefly-protein-enables-visualization-of-roots-in-soil -
Scientists discover an on-off switch for aging cells
Scientists at the Salk Institute have discovered an on-and-off "switch" in cells that may hold the key to healthy aging. This switch points to a way to encourage healthy cells to keep dividing and generating, for example, new lung or liver tissue, even in old age. In our bodies, newly divided cells constantly replenish lungs, skin, liver and other organs. However, most human cells cannot divide indefinitely–with each division, a cellular timekeeper at the ends of chromosomes shortens. When...
https://www.biyologlar.com/scientists-discover-an-on-off-switch-for-aging-cells -
Brain's on-off thirst switch identified
NEW YORK, NY (January 26, 2015)--Neurons that trigger our sense of thirst--and neurons that turn it off--have been identified by Columbia University Medical Center neuroscientists. The paper was published today in the online edition of Nature. For years, researchers have suspected that thirst is regulated by neurons in the subfornical organ (SFO), in the hypothalamus. But it has been difficult to pinpoint exactly which neurons are involved. "When researchers used electrical current to...
https://www.biyologlar.com/brains-on-off-thirst-switch-identified -
Epigenetic signatures that differentiate triple-negative breast cancers
The new study, published in Nature Communications, compares the breast cancer DNA 'methylome' with that of healthy individuals. The methylome provides a new picture of the genome and shows how it is epigenetically 'decorated' with methyl groups, a process known as DNA 'methylation'.
https://www.biyologlar.com/epigenetic-signatures-that-differentiate-triple-negative-breast-cancers -
Fishing impacts on the Great Barrier Reef
New research shows that fishing is having a significant impact on the make-up of fish populations of the Great Barrier Reef. It's long been known that environmental impacts such as climate change and pollution are amongst the drivers of change on the Great Barrier Reef. Now researchers from the ARC Centre of Excellence for Coral Reef Studies (Coral CoE) at James Cook University have found that removing predatory fish such as coral trout and snapper, through fishing, causes significant changes...
https://www.biyologlar.com/fishing-impacts-on-the-great-barrier-reef -
Wheat disease-resistance gene identified, potential to save billions
A gene that can prevent some of the most important wheat diseases has been identified--creating the potential to save more than a billion dollars in lost production in Australia alone each year. In a global collaboration including the University of Sydney's Plant Breeding Institute (PBI), the CSIRO, CIMMYT (Mexico), University of Newcastle, Chinese Academy of Sciences and the Norwegian University of Life Sciences, the gene Lr67 has been identified as providing resistance to three of the most...
https://www.biyologlar.com/wheat-disease-resistance-gene-identified-potential-to-save-billions -
Stem cells might heal damaged lungs
Collectively, such diseases of the airways as emphysema, bronchitis, asthma and cystic fibrosis are the second leading cause of death worldwide.
https://www.biyologlar.com/stem-cells-might-heal-damaged-lungs -
New brain mapping reveals unknown cell types
Using a process known as single cell sequencing, scientists at Karolinska Institutet have produced a detailed map of cortical cell types and the genes active within them. The study, which is published in the journal 'Science', marks the first time this method of analysis has been used on such a large scale on such complex tissue. The team studied over three thousand cells, one at a time, and even managed to identify a number of hitherto unknown types. "If you compare the brain to a fruit...
https://www.biyologlar.com/new-brain-mapping-reveals-unknown-cell-types -
Closing the case on an ancient archeological mystery
Climate change may be responsible for the abrupt collapse of civilization on the fringes of the Tibetan Plateau around 2000 B.C. WSU archaeologist Jade D'Alpoim Guedes and an international team of researchers found that cooling global temperatures at the end of the Holocene Climatic Optimum, a 4,000 year period of warm weather, would have made it impossible for ancient people on the Tibetan Plateau to cultivate millet, their primary food source. Guedes' team's research recently was published...
https://www.biyologlar.com/closing-the-case-on-an-ancient-archeological-mystery -
Restoring vision with stem cells
Age-related macular degeneration (AMRD) could be treated by transplanting photoreceptors produced by the directed differentiation of stem cells, thanks to findings published today by Professor Gilbert Bernier of the University of Montreal and its affiliated Maisonneuve-Rosemont Hospital. ARMD is a common eye problem caused by the loss of cones. Bernier's team has developed a highly effective in vitro technique for producing light sensitive retina cells from human embryonic stem cells. "Our...
https://www.biyologlar.com/restoring-vision-with-stem-cells -
Brazilian beef industry moves to reduce its destruction of rain forests
Expansion of cattle pastures has led to the destruction of huge swaths of rain forest in Brazil, home to the world's largest herd of commercial beef cattle. But a new study led by the University of Wisconsin-Madison's Holly Gibbs shows that market-driven "zero deforestation agreements" have dramatically influenced the behavior of ranchers and the slaughterhouses to which they sell. Publishing today [May 12, 2015] in the journal Conservation Letters, the research team - including other...
https://www.biyologlar.com/brazilian-beef-industry-moves-to-reduce-its-destruction-of-rain-forests -
Are embryonic stem cells and artificial stem cells equivalent?
Harvard Stem Cell Institute (HSCI) researchers at Massachusetts General Hospital and Harvard Medical School have found new evidence suggesting some human induced pluripotent stem cells are the 'functional equivalent' of human embryonic stem cells, a finding that may begin to settle a long running argument. The findings were published this week in Nature Biotechnology. From 1998 until 2007 embryonic stem cells (ES cells) were the only human cells known with the potential to become any other...
https://www.biyologlar.com/are-embryonic-stem-cells-and-artificial-stem-cells-equivalent -
How an RNA gene silences a whole chromosome
Researchers at Caltech have discovered how an abundant class of RNA genes, called long non-coding RNAs (lncRNAs, pronounced link RNAs) can regulate key genes. By studying an important lncRNA, called Xist, the scientists identified how this RNA gathers a group of proteins and ultimately prevents women from having an extra functional X-chromosome--a condition in female embryos that leads to death in early development. These findings mark the first time that researchers have uncovered the detailed...
https://www.biyologlar.com/how-an-rna-gene-silences-a-whole-chromosome -
Great Barrier Reef marine reserves combat coral disease
A new and significant role for marine reserves on the Great Barrier Reef has been revealed, with researchers finding the reserves reduce the prevalence of coral diseases. It's been known for some time that marine reserves are important for maintaining and enhancing fish stocks, but this is the first time marine reserves have been shown to enhance coral health on the Great Barrier Reef. Researchers from the ARC Centre of Excellence for Coral Reef Studies at James Cook University found that...
https://www.biyologlar.com/great-barrier-reef-marine-reserves-combat-coral-disease -
Unpacking embryonic pluripotency
Researchers at EMBL's European Bioinformatics Institute (EMBL-EBI) and the Wellcome Trust- Medical Research Council Cambridge Stem Cell Institute at the University of Cambridge have identified factors that spark the formation of pluripotent cells.
https://www.biyologlar.com/unpacking-embryonic-pluripotency -
Discovery of an embryonic switch for cancer stem cell generation
An international team of scientists, headed by researchers at UC San Diego School of Medicine and UC San Diego Moores Cancer Center, report that decreases in a specific group of proteins trigger changes in the cancer microenvironment that accelerate growth and development of therapy-resistant cancer stem cells (CSCs). The discovery suggests the basis for a potential new therapeutic approach to eradicate blood cancers, which affect more than 1.1 million Americans. In fact, researchers found...
https://www.biyologlar.com/discovery-of-an-embryonic-switch-for-cancer-stem-cell-generation -
Rapid plankton growth in ocean seen as sign of carbon dioxide loading
A microscopic marine alga is thriving in the North Atlantic to an extent that defies scientific predictions, suggesting swift environmental change as a result of increased carbon dioxide in the ocean, a study led a by Johns Hopkins University scientist has found. What these findings mean remains to be seen, however, as does whether the rapid growth in the tiny plankton's population is good or bad news for the planet. Published Thursday in the journal Science, the study details a tenfold...
https://www.biyologlar.com/rapid-plankton-growth-in-ocean-seen-as-sign-of-carbon-dioxide-loading -
Combining adult stem cells with hormone may speed bone fracture healing
A combination of adult stem cells and parathyroid hormone significantly increased new bone formation in laboratory animals and may speed the healing process for human bone fractures caused by osteoporosis, a new study shows. The study is published online by Molecular Therapy, a peer-reviewed journal in the Nature Publishing Group. Researchers used a combination of mesenchymal stem cells, which are derived from bone marrow taken from adults, and parathyroid hormone, also called PTH, which...
https://www.biyologlar.com/combining-adult-stem-cells-with-hormone-may-speed-bone-fracture-healing -
New GTEx findings show how DNA differences influence gene activity, disease susceptibility
Researchers funded by the National Institutes of Health Genotype-Tissue Expression (GTEx) project have created a new and much-anticipated data resource to help establish how differences in an individual's genomic make-up can affect gene activity and contribute to disease. The new resource will enable scientists to examine the underlying genomics of many different human tissues and cells at the same time, and promises to open new avenues to the study and understanding of human biology. GTEx...
https://www.biyologlar.com/new-gtex-findings-show-how-dna-differences-influence-gene-activity-disease-susceptibility -
Nerve cells use each other as maps
When nerve cells form in an embryo they do not start off in the right place but have to be guided to their final position by navigating a kind of molecular and cellular "map" in order to function properly. In a recent research study published in Nature Communications neurobiologist Sara Wilson, Umeå University, found that during embryonic development different parts of the nerve cell are important for guiding other nerve cells into their physical positions. "We found nerve cells do this in...
https://www.biyologlar.com/nerve-cells-use-each-other-as-maps -
Herpes outbreak, other marine viruses linked to coral bleaching event
A study at Oregon State University has concluded that significant outbreaks of viruses may be associated with coral bleaching events, especially as a result of multiple environmental stresses. One such event was documented even as it happened in a three-day period. It showed how an explosion of three viral groups, including a herpes-like virus, occurred just as corals were bleaching in one part of the Great Barrier Reef off the east coast of Australia. The findings, reported in Frontiers in...
https://www.biyologlar.com/herpes-outbreak-other-marine-viruses-linked-to-coral-bleaching-event -
West Coast scientists sound alarm for changing ocean chemistry
The ocean chemistry along the West Coast of North America is changing rapidly because of global carbon dioxide emissions, and the governments of Oregon, California, Washington and British Columbia can take actions now to offset and mitigate the effects of these changes. That is the conclusion of a 20-member panel of leading West Coast ocean scientists, who presented a comprehensive report on Monday outlining a series of recommendations to address the increase in ocean acidification and...
https://www.biyologlar.com/west-coast-scientists-sound-alarm-for-changing-ocean-chemistry -
Researchers identify unique marker on mom's chromosomes in early embryo
Researchers in the University of Georgia's Regenerative Bioscience Center are visually capturing the first process of chromosome alignment and separation at the beginning of mouse development. The findings could lead to answers to questions concerning the mechanisms leading to birth defects and chromosome instability in cancer cells. "We've generated a model that is unique in the world," said Rabindranath De La Fuente, an associate professor in the UGA College of Veterinary Medicine. "Because...
https://www.biyologlar.com/researchers-identify-unique-marker-on-moms-chromosomes-in-early-embryo -
A quartet of genes controls growth of blood stem cells
An important element in getting blood stem cells to multiply outside the body is to understand which of the approximately 20 000 genes in the human body control their growth. A research team at Lund University in Sweden has studied close to 15 000 of these genes alongside each other. The researchers have succeeded in identifying four key genes which, together, govern the growth and multiplication of the stem cells. The study is now being published in the journal Cell Reports. Every day, over...
https://www.biyologlar.com/a-quartet-of-genes-controls-growth-of-blood-stem-cells -
Algae use their 'tails' to gallop and trot like quadrupeds
Long before there were fish swimming in the oceans, tiny microorganisms were using long slender appendages called cilia and flagella to navigate their watery habitats.
https://www.biyologlar.com/algae-use-their-tails-to-gallop-and-trot-like-quadrupeds -
Stem cell therapy improves outcomes in severe heart failure
A new stem cell therapy significantly improved long-term health outcomes in patients with severe and end-stage heart failure in a study presented at the American College of Cardiology's 65th Annual Scientific Session.
https://www.biyologlar.com/stem-cell-therapy-improves-outcomes-in-severe-heart-failure -
A microtubule 'roadway' in the retina helps provide energy for vision
Researchers have discovered a thick band of microtubules in certain neurons in the retina that they believe acts as a transport road for mitochondria that help provide energy required for visual processing. The findings appear in the July issue of The Journal of General Physiology. The retina is a layer of tissue in the back of the eye that converts light into nerve impulses. The retina contains small, specialized neurons called bipolar cells that transmit information from light-sensitive...
https://www.biyologlar.com/a-microtubule-roadway-in-the-retina-helps-provide-energy-for-vision -
DNA damage by ultrashort pulses of intense laser light
DNA damage caused by very low-energy electrons and OH-radicals formed upon irradiation of water by ultrashort pulses of very intense laser light.
https://www.biyologlar.com/dna-damage-by-ultrashort-pulses-of-intense-laser-light -
DNA damage by ultrashort pulses of intense laser light
DNA damage caused by very low-energy electrons and OH-radicals formed upon irradiation of water by ultrashort pulses of very intense laser light.
https://www.biyologlar.com/dna-damage-by-ultrashort-pulses-of-intense-laser-light -
Brain scans show birds of a feather do flock together
The hottest hairstyle, the latest extreme sport, the newest viral stunt -- trends happen for a reason and now scientists have a better understanding of why. In a study using functional magnetic resonance imaging, Virginia Tech Carilion Research Institute scientists found that our inherent risk-taking preferences affect how we view and act on information from other people. The brain scans showed that study participants increased their perceived value of a gamble after seeing other people take...
https://www.biyologlar.com/brain-scans-show-birds-of-a-feather-do-flock-together -
Four newly identified genes could improve rice
The GWAS results for genes that influence flowering dates. The known genes Hd1, Hd2, and Hd6 were located, together with two newly-identified genes that also affect flowering dates.
https://www.biyologlar.com/four-newly-identified-genes-could-improve-rice -
Four newly identified genes could improve rice
The GWAS results for genes that influence flowering dates. The known genes Hd1, Hd2, and Hd6 were located, together with two newly-identified genes that also affect flowering dates.
https://www.biyologlar.com/four-newly-identified-genes-could-improve-rice -
Gene fuels age-related obesity and diabetes
Practically everyone gets fatter as they get older, but some people can blame their genes for the extra padding. Researchers have shown that two different mutations in a gene called ankyrin-B cause cells to suck up glucose faster than normal, fattening them up and eventually triggering the type of diabetes linked to obesity. The more severe of the two mutations, called R1788W, is carried by nearly one million Americans. The milder mutation, known as L1622I, is shared by seven percent of the...
https://www.biyologlar.com/gene-fuels-age-related-obesity-and-diabetes -
Embryonic gene Nanog reverses aging in adult stem cells
The images above show, from left to right, functioning stem cells, stem cells no longer functioning due to Hutchinson-Gilford Progeria syndrome (HGPS), and stem cells previously not functioning
https://www.biyologlar.com/embryonic-gene-nanog-reverses-aging-in-adult-stem-cells -
Embryonic gene Nanog reverses aging in adult stem cells
The images above show, from left to right, functioning stem cells, stem cells no longer functioning due to Hutchinson-Gilford Progeria syndrome (HGPS), and stem cells previously not functioning
https://www.biyologlar.com/embryonic-gene-nanog-reverses-aging-in-adult-stem-cells -
Disease that causes blindness in children tied to new gene
Northwestern Medicine and University of Wisconsin-Madison (UW) scientists have identified a gene that causes severe glaucoma in children.
https://www.biyologlar.com/disease-that-causes-blindness-in-children-tied-to-new-gene -
Uncovering the secrets of immune system invaders
The human immune system is a powerful and wonderful creation. If you cut your skin, your body mobilizes a series of different proteins and cells to heal the cut. If you are infected by a virus or bacteria, your immune system responds with a series of cells that attack the invader and neutralize it. But sometimes invaders find ways to exploit the very cells that are designed to protect us. Tuberculosis (Mycobacterium tuberculosis) and its lesser-known (and less virulent) relative Mycobacterium...
https://www.biyologlar.com/uncovering-the-secrets-of-immune-system-invaders -
How a single molecule turns one immune cell into another
All it takes is one molecule to reprogram an antibody-producing B cell into a scavenging macrophage. This transformation is possible, new evidence shows, because the molecule (C/EBPa, a transcription factor) "short-circuits" the cells so that they re-express genes reserved for embryonic development. The findings appear July 30 in Stem Cell Reports, the journal of the International Society for Stem Cell Research. Over the past 28 years, researchers have shown that a number of specialized cell...
https://www.biyologlar.com/how-a-single-molecule-turns-one-immune-cell-into-another