Toplam 113 içerik listeleniyor
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Primate evolution in the fast lane
The pace of evolution is typically measured in millions of years, as random, individual mutations accumulate over generations, but researchers at Cornell and Bar-Ilan Universities have uncovered a new mechanism for mutation in primates that is rapid, coordinated, and aggressive. The discovery raises questions about the accuracy of using the more typical mutation process as an estimate to date when two species diverged, as well as the extent to which this and related enzymes played a role in...
https://www.biyologlar.com/primate-evolution-in-the-fast-lane-haber-8133 -
Attacking a rare disease at its source with gene therapy
Treating the rare disease MPS I is a challenge. MPS I, caused by the deficiency of a key enzyme called IDUA, eventually leads to the abnormal accumulation of certain molecules and cell death.
https://www.biyologlar.com/attacking-a-rare-disease-at-its-source-with-gene-therapy-haber-8765 -
Havuç sağlıklıdır, ancak havucun faydalarını aktif bir enzim ortaya çıkarır
Havuç, A vitaminin öncüsü olan iyi bir beta-karoten kaynağıdır. Ancak bu besinin faydalarını tam olarak alabilmek ve A vitamininin üretimini sağlayabilmek için aktif bir enzime ihtiyaç vardır.
https://www.biyologlar.com/havuc-sagliklidir-ancak-havucun-faydalarini-aktif-bir-enzim-ortaya-cikarir -
Havuç sağlıklıdır, ancak havucun faydalarını aktif bir enzim ortaya çıkarır
Havuç, A vitaminin öncüsü olan iyi bir beta-karoten kaynağıdır. Ancak bu besinin faydalarını tam olarak alabilmek ve A vitamininin üretimini sağlayabilmek için aktif bir enzime ihtiyaç vardır.
https://www.biyologlar.com/havuc-sagliklidir-ancak-havucun-faydalarini-aktif-bir-enzim-ortaya-cikarir -
Simple technology makes CRISPR gene editing cheaper
University of California, Berkeley, researchers have discovered a much cheaper and easier way to target a hot new gene editing tool, CRISPR-Cas9, to cut or label DNA. The CRISPR-Cas9 technique, invented three years ago at UC Berkeley, has taken genomics by storm, with its ability to latch on to a very specific sequence of DNA and cut it, inactivating genes with ease. This has great promise for targeted gene therapy to cure genetic diseases, and for discovering the causes of disease. The...
https://www.biyologlar.com/simple-technology-makes-crispr-gene-editing-cheaper -
Polymerase Chain Reaction (PCR)
Polymerase chain reaction (PCR) allows researchers to amplify DNA in a test tube. This process uses an enzyme derived from heat-resistant bacteria. The steps of PCR are driven by changes in temperature. Originally created for DNA Interactive ( http://www.dnai.org ). TRANSCRIPT: Polymerase chain reaction (PCR) is a process where many copies of a specific piece of DNA can be made. This is known as amplification. Double-stranded DNA (red) unwinds and separates when the temperature is increased....
https://www.biyologlar.com/polymerase-chain-reaction-pcr -
Stanford researchers genetically engineer yeast to produce opioids
For thousands of years, people have used yeast to ferment wine, brew beer and leaven bread. Now researchers at Stanford have genetically engineered yeast to make painkilling medicines, a breakthrough that heralds a faster and potentially less expensive way to produce many different types of plant-based medicines. Writing today in Science, the Stanford engineers describe how they reprogrammed the genetic machinery of baker's yeast so that these fast-growing cells could convert sugar into...
https://www.biyologlar.com/stanford-researchers-genetically-engineer-yeast-to-produce-opioids -
ELISA TESTİ
Enzyme-linked immunosorbent assay (ELISA), also known as an enzyme immunoassay (EIA), is a biochemical technique used mainly in immunology to detect the presence of an antibody or an antigen in a sample. The video shown is Proteintech Group's preferred method.
https://www.biyologlar.com/elisa-testi -
Enzyme controlling metastasis of breast cancer identified
Researchers at the University of California, San Diego School of Medicine have identified an enzyme that controls the spread of breast cancer. The findings, reported in the current issue of PNAS, offer hope for the leading cause of breast cancer mortality worldwide. An estimated 40,000 women in America will die of breast cancer in 2014, according to the American Cancer Society. "The take-home message of the study is that we have found a way to target breast cancer metastasis through a pathway...
https://www.biyologlar.com/enzyme-controlling-metastasis-of-breast-cancer-identified -
Firefly protein enables visualization of roots in soil
Plants form a vast network of below-ground roots that search soil for needed resources. The structure and function of this root network can be highly adapted to particular environments such as desert soils where plants like Mesquite develop tap roots capable of digging 50 meters deep to capture precious water resources. Excavation of root systems reveals these kinds of adaptations but is laborious, time consuming, and does not provide information on how growing roots behave. A new imaging tool...
https://www.biyologlar.com/firefly-protein-enables-visualization-of-roots-in-soil -
Scientists discover an on-off switch for aging cells
Scientists at the Salk Institute have discovered an on-and-off "switch" in cells that may hold the key to healthy aging. This switch points to a way to encourage healthy cells to keep dividing and generating, for example, new lung or liver tissue, even in old age. In our bodies, newly divided cells constantly replenish lungs, skin, liver and other organs. However, most human cells cannot divide indefinitely–with each division, a cellular timekeeper at the ends of chromosomes shortens. When...
https://www.biyologlar.com/scientists-discover-an-on-off-switch-for-aging-cells -
Chip-based technology enables reliable direct detection of Ebola virus
A team led by researchers at UC Santa Cruz has developed chip-based technology for reliable detection of Ebola virus and other viral pathogens. The system uses direct optical detection of viral molecules and can be integrated into a simple, portable instrument for use in field situations where rapid, accurate detection of Ebola infections is needed to control outbreaks. Laboratory tests using preparations of Ebola virus and other hemorrhagic fever viruses showed that the system has the...
https://www.biyologlar.com/chip-based-technology-enables-reliable-direct-detection-of-ebola-virus -
Snake venom helps hydrogels stop the bleeding
A nanofiber hydrogel infused with snake venom may be the best material to stop bleeding quickly, according to Rice University scientists. The hydrogel called SB50 incorporates batroxobin, a venom produced by two species of South American pit viper. It can be injected as a liquid and quickly turns into a gel that conforms to the site of a wound, keeping it closed, and promotes clotting within seconds. Rice chemist Jeffrey Hartgerink, lead author Vivek Kumar and their colleagues reported their...
https://www.biyologlar.com/snake-venom-helps-hydrogels-stop-the-bleeding -
In a role reversal, RNAs proofread themselves
Cold Spring Harbor, NY - Building a protein is a lot like a game of telephone: information is passed along from one messenger to another, creating the potential for errors every step of the way. There are separate, specialized enzymatic machines that proofread at each step, ensuring that the instructions encoded in our DNA are faithfully translated into proteins. Scientists at Cold Spring Harbor Laboratory (CSHL) have uncovered a new quality control mechanism along this path, but in a...
https://www.biyologlar.com/in-a-role-reversal-rnas-proofread-themselves -
Role of telomeres in plant stem cells discovered
The role played by telomeres in mammalian cells has been known for several years. It is also known that these non-coding DNA sequences, which are found at the ends of the chromosomes, protect them and are necessary to ensure correct cell division.
https://www.biyologlar.com/role-of-telomeres-in-plant-stem-cells-discovered -
Broad, MIT scientists overcome key CRISPR-Cas9 genome editing hurdle
Researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT have engineered changes to the revolutionary CRISPR-Cas9 genome editing system that significantly cut down on "off-target" editing errors. The refined technique addresses one of the major technical issues in the use of genome editing. The CRISPR-Cas9 system works by making a precisely targeted modification in a cell's DNA. The protein Cas9 alters the DNA at a location that is specified by...
https://www.biyologlar.com/broad-mit-scientists-overcome-key-crispr-cas9-genome-editing-hurdle -
Nano-walkers take speedy leap forward with first rolling DNA-based motor
Physical chemists have devised a rolling DNA-based motor that's 1,000 times faster than any other synthetic DNA motor, giving it potential for real-world applications, such as disease diagnostics. Nature Nanotechnology is publishing the finding. "Unlike other synthetic DNA-based motors, which use legs to 'walk' like tiny robots, ours is the first rolling DNA motor, making it far faster and more robust," says Khalid Salaita, the Emory University chemist who led the research. "It's like the...
https://www.biyologlar.com/nano-walkers-take-speedy-leap-forward-with-first-rolling-dna-based-motor -
How an RNA gene silences a whole chromosome
Researchers at Caltech have discovered how an abundant class of RNA genes, called long non-coding RNAs (lncRNAs, pronounced link RNAs) can regulate key genes. By studying an important lncRNA, called Xist, the scientists identified how this RNA gathers a group of proteins and ultimately prevents women from having an extra functional X-chromosome--a condition in female embryos that leads to death in early development. These findings mark the first time that researchers have uncovered the detailed...
https://www.biyologlar.com/how-an-rna-gene-silences-a-whole-chromosome -
Genetically modified E. coli pump out morphine precursor
A common gut microbe could soon be offering us pain relief. Japanese bioengineers have tweaked Escherichia coli genes so that they pump out thebaine, a morphine precursor that can be modified to make painkillers. The genetically modified E. coli produces 300 times more thebaine with minimal risk of unregulated use compared to a recently developed method involving yeast. "Morphine has a complex molecular structure; because of this, the production of morphine and similar painkillers is expensive...
https://www.biyologlar.com/genetically-modified-e-coli-pump-out-morphine-precursor -
Discovery of an embryonic switch for cancer stem cell generation
An international team of scientists, headed by researchers at UC San Diego School of Medicine and UC San Diego Moores Cancer Center, report that decreases in a specific group of proteins trigger changes in the cancer microenvironment that accelerate growth and development of therapy-resistant cancer stem cells (CSCs). The discovery suggests the basis for a potential new therapeutic approach to eradicate blood cancers, which affect more than 1.1 million Americans. In fact, researchers found...
https://www.biyologlar.com/discovery-of-an-embryonic-switch-for-cancer-stem-cell-generation -
Researchers enhance CRISPR gene editing technology
Scientists have developed a process that improves the efficiency of CRISPR, an up-and-coming technology used to edit DNA. "Scientists all over the world are using CRISPR right now in their studies, but the technology is not as functional as it could be," says Haoquan Wu, Ph.D., who enhanced the process and is a biomedical scientist at Texas Tech University Health Sciences Center El Paso (TTUHSC El Paso). CRISPR is a groundbreaking technology that allows scientists to modify genes. Two key...
https://www.biyologlar.com/researchers-enhance-crispr-gene-editing-technology -
Researchers build molecule that could significantly reduce brain damage in stroke victims
Research teams separated by 14 hours and 9,000 miles have collaborated to advance prospective treatment for the world's second-leading cause of death. University of Nebraska-Lincoln chemists partnered with medical researchers from the National University of Singapore to develop a molecule that can inhibit an enzyme linked with the onset of stroke. Most strokes occur when a disruption of blood flow prevents oxygen and glucose from reaching brain tissue, ultimately killing neurons and other...
https://www.biyologlar.com/researchers-build-molecule-that-could-significantly-reduce-brain-damage-in-stroke-victims -
Decaying RNA molecules tell a story
Once messenger RNA (mRNA) has done its job - conveying the information to produce the proteins necessary for a cell to function - it is no longer required and is degraded. Scientists have long thought that the decay started after translation was complete and that decaying RNA molecules provided little biological information. Now a team from EMBL Heidelberg and Stanford University led by Lars Steinmetz has turned this on its head in an article published in Cell. The researchers have shown that...
https://www.biyologlar.com/decaying-rna-molecules-tell-a-story -
Programlı hücre ölümü
Sorunuzun Cevabı burada var. www.biyologlar.com/index.php?option=com_...atid=25&id=1881#2266 Animasyon: Apoptosis: Overview www.promega.com/paguide/animation/selector.htm?coreName=apop01 Apoptosis: Intrinsic Triggers www.promega.com/paguide/animation/selector.htm?coreName=apop02 Apoptozis hakkında bilgiler Programlanmış hücre ölümü Programlanmış hücre ölümü (PHÖ veya PCD), herhangi bir hücrenin, hücre içi bir programla ölmesinin planlaması ve...
https://www.biyologlar.com/programli-hucre-olumu -
Gene controls regeneration of injured muscle by adult stem cells
A key gene enables the repair of injured muscle throughout life. This is the finding of a study in mice led by researchers at NYU Langone Medical Center and the University of Colorado at Boulder, and published online July 21 in Cell Reports.
https://www.biyologlar.com/gene-controls-regeneration-of-injured-muscle-by-adult-stem-cells -
Alert to biologists: Ribosomes can translate the 'untranslated region' of messenger RNA
In what appears to be an unexpected challenge to a long-accepted fact of biology, Johns Hopkins researchers say they have found that ribosomes -- the molecular machines in all cells that build proteins -- can sometimes do so even within the so-called untranslated regions of the ribbons of genetic material known as messenger RNA (mRNA). "This is an exciting find that generates a whole new set of questions for researchers," says Rachel Green, Ph.D., a Howard Hughes Medical Institute investigator...
https://www.biyologlar.com/alert-to-biologists-ribosomes-can-translate-the-untranslated-region-of-messenger-rna -
Scientists blueprint tiny cellular 'nanomachine'
Scientists have drawn up molecular blueprints of a tiny cellular 'nanomachine', whose evolution is an extraordinary feat of nature, by using one of the brightest X-ray sources on Earth. The scientists produced the structural map of this nanomachine - diacylglycerol kinase - by using a "hit and run" crystallography technique. In doing so, they have been able to understand how the tiny enzyme performs critical cellular duties - answering questions that have been on the table for over 50 years...
https://www.biyologlar.com/scientists-blueprint-tiny-cellular-nanomachine -
DNA research offers clues on cell mutation
A team of researchers from Colorado State University has been studying DNA damage in living cells to learn more about how genetic abnormalities arise. It has long been known that DNA molecules in every cell get constantly damaged by things from the outside environment, like sunlight, cigarette smoke and radiation. However, more recently researchers have discovered that sources from within the cell itself can sometimes be even more damaging. DNA, or deoxyribonucleic acid, is found in the...
https://www.biyologlar.com/dna-research-offers-clues-on-cell-mutation -
DNA research offers clues on cell mutation
A team of researchers from Colorado State University has been studying DNA damage in living cells to learn more about how genetic abnormalities arise. It has long been known that DNA molecules in every cell get constantly damaged by things from the outside environment, like sunlight, cigarette smoke and radiation. However, more recently researchers have discovered that sources from within the cell itself can sometimes be even more damaging. DNA, or deoxyribonucleic acid, is found in the...
https://www.biyologlar.com/dna-research-offers-clues-on-cell-mutation -
Some bacterial CRISPRs can snip RNA, too
You've probably seen news stories about the highly lauded, much-discussed genome editing system CRISPR/Cas9.
https://www.biyologlar.com/some-bacterial-crisprs-can-snip-rna-too -
Some bacterial CRISPRs can snip RNA, too
You've probably seen news stories about the highly lauded, much-discussed genome editing system CRISPR/Cas9.
https://www.biyologlar.com/some-bacterial-crisprs-can-snip-rna-too -
Unlocking the secrets of gene expression
Your DNA governs more than just what color your eyes are and whether you can curl your tongue.
https://www.biyologlar.com/unlocking-the-secrets-of-gene-expression -
A 'supergene' underlies genetic differences sexual behaviour in male ruff
The ruff is a Eurasian shorebird that has a spectacular lekking behaviour where highly ornamented males compete for females. Now two groups report that males with alternative reproductive strategies carry a chromosomal rearrangement that has been maintained as a balanced genetic polymorphism for about 4 million years. The two studies, one led by scientists at Uppsala university, are published today in Nature Genetics. Three different types of ruff males occur at the leks of this species....
https://www.biyologlar.com/a-supergene-underlies-genetic-differences-sexual-behaviour-in-male-ruff -
An enzyme enigma discovered in the abyss
Scientists at the Universities of Bristol and Newcastle have uncovered the secret of the 'Mona Lisa of chemical reactions' - in a bacterium that lives at the bottom of the Pacific Ocean.
https://www.biyologlar.com/an-enzyme-enigma-discovered-in-the-abyss -
An enzyme enigma discovered in the abyss
Scientists at the Universities of Bristol and Newcastle have uncovered the secret of the 'Mona Lisa of chemical reactions' - in a bacterium that lives at the bottom of the Pacific Ocean.
https://www.biyologlar.com/an-enzyme-enigma-discovered-in-the-abyss -
Scientists find that cancer can arise from changes in the proteins that package DNA
In some cancers, including chondroblastoma and a rare form of childhood sarcoma, a mutation in histone H3 reduces global levels of methylation (dark areas) in tumor cells
https://www.biyologlar.com/scientists-find-that-cancer-can-arise-from-changes-in-the-proteins-that-package-dna -
Scientists capture the elusive structure of essential digestive enzyme
Stylized graphic of SEC-SAXS data (with cyan cross-section showing the elution profile and magenta cross-section showing scattering profile) and the structure of the activated phenylalanine hydroxylase
https://www.biyologlar.com/scientists-capture-the-elusive-structure-of-essential-digestive-enzyme -
Scientists capture the elusive structure of essential digestive enzyme
Stylized graphic of SEC-SAXS data (with cyan cross-section showing the elution profile and magenta cross-section showing scattering profile) and the structure of the activated phenylalanine hydroxylase
https://www.biyologlar.com/scientists-capture-the-elusive-structure-of-essential-digestive-enzyme -
Heme, a poisonous nutrient, tracked by 'Green Lantern' sensor
Tailor-made ratiometric sensors make baker's yeast cells light up green, as Georgia Tech scientists use it to track the movements of the essential toxin heme
https://www.biyologlar.com/heme-a-poisonous-nutrient-tracked-by-green-lantern-sensor -
Heme, a poisonous nutrient, tracked by 'Green Lantern' sensor
Tailor-made ratiometric sensors make baker's yeast cells light up green, as Georgia Tech scientists use it to track the movements of the essential toxin heme
https://www.biyologlar.com/heme-a-poisonous-nutrient-tracked-by-green-lantern-sensor -
DNA breaks in nerve cells' ancestors cluster in specific genes
The genome of developing brain cells harbors 27 clusters or hotspots where its DNA is much more likely to break in some places than others, researchers from the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital, Harvard Medical School, and the Howard Hughes Medical Institute report in the journal Cell. Those hotspots appear in genes associated with brain tumors and a number of neurodevelopmental and neuropsychiatric conditions, raising new questions about these...
https://www.biyologlar.com/dna-breaks-in-nerve-cells-ancestors-cluster-in-specific-genes -
DNA breaks in nerve cells' ancestors cluster in specific genes
The genome of developing brain cells harbors 27 clusters or hotspots where its DNA is much more likely to break in some places than others, researchers from the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital, Harvard Medical School, and the Howard Hughes Medical Institute report in the journal Cell. Those hotspots appear in genes associated with brain tumors and a number of neurodevelopmental and neuropsychiatric conditions, raising new questions about these...
https://www.biyologlar.com/dna-breaks-in-nerve-cells-ancestors-cluster-in-specific-genes -
Cell death: How a protein drives immune cells to suicide
The best hiding place often lies behind enemy lines, as many bacteria such as the pathogens responsible for tuberculosis or typhoid have realized. They invade immune cells and can survive there, well hidden, for some time. To eliminate such invaders, the host macrophages can initiate a suicide program. Together with researchers at the Novartis Institute for Biomedical Research and ETH Zurich, the team led by Prof. Sebastian Hiller from the Biozentrum at the University of Basel has shown for the...
https://www.biyologlar.com/cell-death-how-a-protein-drives-immune-cells-to-suicide -
Cell death: How a protein drives immune cells to suicide
The best hiding place often lies behind enemy lines, as many bacteria such as the pathogens responsible for tuberculosis or typhoid have realized. They invade immune cells and can survive there, well hidden, for some time. To eliminate such invaders, the host macrophages can initiate a suicide program. Together with researchers at the Novartis Institute for Biomedical Research and ETH Zurich, the team led by Prof. Sebastian Hiller from the Biozentrum at the University of Basel has shown for the...
https://www.biyologlar.com/cell-death-how-a-protein-drives-immune-cells-to-suicide -
Deep-sea bacteria could help neutralize greenhouse gas, researchers find
A type of bacteria plucked from the bottom of the ocean could be put to work neutralizing large amounts of industrial carbon dioxide in the Earth's atmosphere, a group of University of Florida researchers has found. Carbon dioxide, a major contributor to the buildup of atmospheric greenhouse gases, can be captured and neutralized in a process known as sequestration. Most atmospheric carbon dioxide is produced from fossil fuel combustion, a waste known as flue gas. But converting the carbon...
https://www.biyologlar.com/deep-sea-bacteria-could-help-neutralize-greenhouse-gas-researchers-find -
Protein structure paves the way for new broad spectrum antifungals
This ribbon diagram shows two views of the structure of the enzyme Tps2 as it removes a phosphate from a sugar molecule (yellow, orange and red).
https://www.biyologlar.com/protein-structure-paves-the-way-for-new-broad-spectrum-antifungals -
Nobel laureate, new technologies show how cancer cells protect chromosomes from decay
Protective telomeres are augmented by freely diffusing telomerase.
https://www.biyologlar.com/nobel-laureate-new-technologies-show-how-cancer-cells-protect-chromosomes-from-decay -
Nobel laureate, new technologies show how cancer cells protect chromosomes from decay
Protective telomeres are augmented by freely diffusing telomerase.
https://www.biyologlar.com/nobel-laureate-new-technologies-show-how-cancer-cells-protect-chromosomes-from-decay -
Scientists uncover the way a common cell enzyme alerts the body to invading bacteria
Biomedical investigators at Cedars-Sinai have identified an enzyme found in all human cells that alerts the body to invading bacteria and jump-starts the immune system.
https://www.biyologlar.com/scientists-uncover-the-way-a-common-cell-enzyme-alerts-the-body-to-invading-bacteria -
Cracking the mystery of Zika virus replication
This is the structure of the ZIKV helicase in complex with RNA.
https://www.biyologlar.com/cracking-the-mystery-of-zika-virus-replication