Toplam 189 içerik listeleniyor
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Drug-resistant genes spread through environment, not meat products
In the first study to use new methods to track antibiotic resistance through the process of intensively farming and slaughtering cattle, scientists have discovered a "startling" lack of resistance genes in meat.
https://www.biyologlar.com/drug-resistant-genes-spread-through-environment-not-meat-products-haber-8719 -
Bir Aşı Hikayesi: Olmak Ya Da Olmamak
Aşılama zayıflatılmış virüs ya da bakterilerin ya da bunların antijenik parçalarının vücuda verilerek bağışıklık elde edilmesidir. Bu sayede morbiditesi ve mortalitesi yüksek olan bulaşıcı hastalıkların engellenmesi ya da zarar verme oranının azaltılması amaçlanır.
https://www.biyologlar.com/bir-asi-hikayesi-olmak-ya-da-olmamak -
Bir Aşı Hikayesi: Olmak Ya Da Olmamak
Aşılama zayıflatılmış virüs ya da bakterilerin ya da bunların antijenik parçalarının vücuda verilerek bağışıklık elde edilmesidir. Bu sayede morbiditesi ve mortalitesi yüksek olan bulaşıcı hastalıkların engellenmesi ya da zarar verme oranının azaltılması amaçlanır.
https://www.biyologlar.com/bir-asi-hikayesi-olmak-ya-da-olmamak -
Highly efficient CRISPR knock-in in mouse
Genome editing using CRISPR/Cas system has enabled direct modification of the mouse genome in fertilized mouse eggs, leading to rapid, convenient, and efficient one-step production of knockout mice without embryonic stem cells. In contrast to the ease of targeted gene deletion, the complementary application, called targeted gene cassette insertion or knock-in, in fertilized mouse eggs by CRISPR/Cas mediated genome editing still remains a tough challenge. Professor Kohichi Tanaka and Dr. Tomomi...
https://www.biyologlar.com/highly-efficient-crispr-knock-in-in-mouse -
Improving the delivery of chemotherapy with graphene
A new study published in IOP Publishing's journal 2D Materials has proposed using graphene as an alternative coating for catheters to improve the delivery of chemotherapy drugs. The research suggests that placing graphene - an extremely thin sheet of carbon atoms - on the internal surfaces of intravenous catheters commonly used to deliver chemotherapy drugs into a patient's body will improve the efficacy of treatments, and reduce the potential of the catheters breaking. The study indicates...
https://www.biyologlar.com/improving-the-delivery-of-chemotherapy-with-graphene -
New discovery in living cell signaling
A breakthrough discovery into how living cells process and respond to chemical information could help advance the development of treatments for a large number of cancers and other cellular disorders that have been resistant to therapy. An international collaboration of researchers, led by scientists with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley, have unlocked the secret behind the activation of the...
https://www.biyologlar.com/new-discovery-in-living-cell-signaling -
Stem-cell approach shows promise for Duchenne muscular dystrophy
Researchers have shown that transplanting stem cells derived from normal mouse blood vessels into the hearts of mice that model the pathology associated with Duchenne muscular dystrophy (DMD) prevents the decrease in heart function associated with DMD. Their findings appear in the journal Stem Cells Translational Medicine. Duchenne muscular dystrophy is a genetic disorder caused by a mutation in the gene for dystrophin, a protein that anchors muscle cells in place when they contract. Without...
https://www.biyologlar.com/stem-cell-approach-shows-promise-for-duchenne-muscular-dystrophy -
Kene İle Bulaşan Hastalıklar
ÖZET Parazitlerin neden olduğu hastalıklar önemli sağlık problemidir. Endoparazit ve ektoparaziter hastalıklar mevcuttur. Kenelerle bulaşan hastalıklar en sık görülen vektör kaynaklı hastalıklardır. Keneler bakteri, virüs spiroket, protozoa, nematod ve toksinler gibi patojenleri yayabilir ve böylece ektoparaziter kaynaklı hastalıklara sebep olurlar. Ülkemizde keneler için iklim koşulları, bitki örtüsü ve yüzey şekli bakımından uygun koşullar vardır. Bu...
https://www.biyologlar.com/kene-ile-bulasan-hastaliklar -
Stanford researchers genetically engineer yeast to produce opioids
For thousands of years, people have used yeast to ferment wine, brew beer and leaven bread. Now researchers at Stanford have genetically engineered yeast to make painkilling medicines, a breakthrough that heralds a faster and potentially less expensive way to produce many different types of plant-based medicines. Writing today in Science, the Stanford engineers describe how they reprogrammed the genetic machinery of baker's yeast so that these fast-growing cells could convert sugar into...
https://www.biyologlar.com/stanford-researchers-genetically-engineer-yeast-to-produce-opioids -
Bakteriyofaj Nedir ?
Bakteri yiyen canlı bakterilerin büyümesine engel olan onları eriten ve ancak elektron mikroskopla görülebilen bir ültravirüs. Süzgeçlerden geçen ve kültürden kültüre nakledilmesi mümkün olan bu ultra- virüs bakteri kolonilerinde görülebilen değişiklikler yapabilmekte ve bakteri hücrelerini hiç bir artık bırakmadan eritebilmektedir. bakteriyofajlar ın bilhassa zararlı bakterilerden meydana gelen çeşitli salgınlarda bakterileri yok etmek suretiyle önemli rolleri...
https://www.biyologlar.com/bakteriyofaj-nedir- -
Stem cells from teeth can make brain-like cells
University of Adelaide researchers have discovered that stem cells taken from teeth can grow to resemble brain cells, suggesting they could one day be used in the brain as a therapy for stroke.
https://www.biyologlar.com/stem-cells-from-teeth-can-make-brain-like-cells -
Using DNA origami to build nanodevices of the future
Scientists have been studying ways to use synthetic DNA as a building block for smaller and faster devices. DNA has the advantage of being inherently "coded". Each DNA strand is formed of one of four "codes" that can link to only one complementary code each, thus binding two DNA strands together. Scientists are using this inherent coding to manipulate and "fold" DNA to form "origami nanostructures": extremely small two- and three-dimensional shapes that can then be used as construction material...
https://www.biyologlar.com/using-dna-origami-to-build-nanodevices-of-the-future -
Using DNA origami to build nanodevices of the future
Scientists have been studying ways to use synthetic DNA as a building block for smaller and faster devices. DNA has the advantage of being inherently "coded". Each DNA strand is formed of one of four "codes" that can link to only one complementary code each, thus binding two DNA strands together. Scientists are using this inherent coding to manipulate and "fold" DNA to form "origami nanostructures": extremely small two- and three-dimensional shapes that can then be used as construction material...
https://www.biyologlar.com/using-dna-origami-to-build-nanodevices-of-the-future -
Researchers use human stem cells to create light-sensitive retina in a dish
Using a type of human stem cell, Johns Hopkins researchers say they have created a three-dimensional complement of human retinal tissue in the laboratory, which notably includes functioning photoreceptor cells capable of responding to light, the first step in the process of converting it into visual images.
https://www.biyologlar.com/researchers-use-human-stem-cells-to-create-light-sensitive-retina-in-a-dish -
New method to grow zebrafish embryonic stem cells can regenerate whole fish
Zebrafish, a model organism that plays an important role in biological research and the discovery and development of new drugs and cell-based therapies, can form embryonic stem cells (ESCs).
https://www.biyologlar.com/new-method-to-grow-zebrafish-embryonic-stem-cells-can-regenerate-whole-fish -
Brain's on-off thirst switch identified
NEW YORK, NY (January 26, 2015)--Neurons that trigger our sense of thirst--and neurons that turn it off--have been identified by Columbia University Medical Center neuroscientists. The paper was published today in the online edition of Nature. For years, researchers have suspected that thirst is regulated by neurons in the subfornical organ (SFO), in the hypothalamus. But it has been difficult to pinpoint exactly which neurons are involved. "When researchers used electrical current to...
https://www.biyologlar.com/brains-on-off-thirst-switch-identified -
Snake venom helps hydrogels stop the bleeding
A nanofiber hydrogel infused with snake venom may be the best material to stop bleeding quickly, according to Rice University scientists. The hydrogel called SB50 incorporates batroxobin, a venom produced by two species of South American pit viper. It can be injected as a liquid and quickly turns into a gel that conforms to the site of a wound, keeping it closed, and promotes clotting within seconds. Rice chemist Jeffrey Hartgerink, lead author Vivek Kumar and their colleagues reported their...
https://www.biyologlar.com/snake-venom-helps-hydrogels-stop-the-bleeding -
Role of telomeres in plant stem cells discovered
The role played by telomeres in mammalian cells has been known for several years. It is also known that these non-coding DNA sequences, which are found at the ends of the chromosomes, protect them and are necessary to ensure correct cell division.
https://www.biyologlar.com/role-of-telomeres-in-plant-stem-cells-discovered -
Epigenetic signatures that differentiate triple-negative breast cancers
The new study, published in Nature Communications, compares the breast cancer DNA 'methylome' with that of healthy individuals. The methylome provides a new picture of the genome and shows how it is epigenetically 'decorated' with methyl groups, a process known as DNA 'methylation'.
https://www.biyologlar.com/epigenetic-signatures-that-differentiate-triple-negative-breast-cancers -
Stem cells might heal damaged lungs
Collectively, such diseases of the airways as emphysema, bronchitis, asthma and cystic fibrosis are the second leading cause of death worldwide.
https://www.biyologlar.com/stem-cells-might-heal-damaged-lungs -
EMBO Conference Series Chemical Biology 2012
Latest News•Registration is open! •Event poster is now available for download Why You Should Attend•SummaryChemical Biology is a quickly growing highly interdisciplinary field, which investigates biological questions by using chemical strategies and tools. It has emerged to become an important and central discipline by itself complementing areas such as medicinal chemistry, pharmacology, cell biology, structural biology and biochemistry. Researchers in Chemical Biology find...
https://www.biyologlar.com/embo-conference-series-chemical-biology-2012 -
Rosa dominica ile ilgili elinde kaynak olan varmı?
Familyası: Gülgillerden, Rosengaewchse, Rosaceae Drugları: Gül çiçeğinin yaprakları; Rossae flos (eskiden; Flores Rosae Gülün çiçek yaprakları kurutularak çay yapımında veya su buharı ile damıtılarak ve yahut da ekstresi yapılarak Gül yağı (gül esansı) elde edilir. Giriş: Vatanının Türkiye olduğu tahmin edilen Gülün günümüzde 400’ den fazla çeşidi vardır. Bizi ilgilendiren Isparta gülü (Rosa damacena) ve Mayıs gülü (Rosa cenlifloria) en...
https://www.biyologlar.com/rosa-dominica-ile-ilgili-elinde-kaynak-olan-varmi -
Functional human liver cells grown in the lab
In new research appearing in the prestigious journal Nature Biotechnology, an international research team led by The Hebrew University of Jerusalem describes a new technique for growing human hepatocytes in the laboratory. This groundbreaking development could help advance a variety of liver-related research and applications, from studying drug toxicity to creating bio-artificial liver support for patients awaiting transplantations. The liver is the largest internal organ in the human body,...
https://www.biyologlar.com/functional-human-liver-cells-grown-in-the-lab -
Scientists create functional liver cells from stem cells
The liver plays a critical role in human metabolism. As the gatekeeper of the digestive track, this massive organ is responsible for drug breakdown and is therefore the first to be injured due to overdose or misuse. Evaluating this drug-induced liver injury is a critical part of pharmaceutical drug discovery and must be carried out on human liver cells. Regretfully, human liver cells, called hepatocytes, are in scarce supply as they can only be isolated from donated organs. Now, in research...
https://www.biyologlar.com/scientists-create-functional-liver-cells-from-stem-cells -
Neurons constantly rewrite their DNA
Johns Hopkins scientists have discovered that neurons are risk takers: They use minor "DNA surgeries" to toggle their activity levels all day, every day. Since these activity levels are important in learning, memory and brain disorders, the researchers think their finding will shed light on a range of important questions. A summary of the study will be published online in the journal Nature Neuroscience on April 27. "We used to think that once a cell reaches full maturation, its DNA is totally...
https://www.biyologlar.com/neurons-constantly-rewrite-their-dna -
Nano-walkers take speedy leap forward with first rolling DNA-based motor
Physical chemists have devised a rolling DNA-based motor that's 1,000 times faster than any other synthetic DNA motor, giving it potential for real-world applications, such as disease diagnostics. Nature Nanotechnology is publishing the finding. "Unlike other synthetic DNA-based motors, which use legs to 'walk' like tiny robots, ours is the first rolling DNA motor, making it far faster and more robust," says Khalid Salaita, the Emory University chemist who led the research. "It's like the...
https://www.biyologlar.com/nano-walkers-take-speedy-leap-forward-with-first-rolling-dna-based-motor -
An alternative TALEN/CRISPR-mediated gene insertion technique described in detail
A streamlined protocol for an alternative gene insertion method using genome editing technologies, the PITCh (Precise Integration into Target Chromosome) system, has been reported in Nature Protocols by Specially Appointed Lecturer Tetsushi Sakuma, Professor Takashi Yamamoto, Specially Appointed Associate Professor Ken-Ichi T Suzuki, and their colleagues at Hiroshima University, Japan. The PITCh system is more convenient and effective than existing methods for inserting foreign DNA into...
https://www.biyologlar.com/an-alternative-talencrispr-mediated-gene-insertion-technique-described-in-detail -
An alternative TALEN/CRISPR-mediated gene insertion technique described in detail
A streamlined protocol for an alternative gene insertion method using genome editing technologies, the PITCh (Precise Integration into Target Chromosome) system, has been reported in Nature Protocols by Specially Appointed Lecturer Tetsushi Sakuma, Professor Takashi Yamamoto, Specially Appointed Associate Professor Ken-Ichi T Suzuki, and their colleagues at Hiroshima University, Japan. The PITCh system is more convenient and effective than existing methods for inserting foreign DNA into...
https://www.biyologlar.com/an-alternative-talencrispr-mediated-gene-insertion-technique-described-in-detail -
Novel stem cell line avoids risk of introducing transplanted tumors
Human pluripotent stem cells (hPSC) can become any type of cell in the adult body, offering great potential in disease modeling, drug discovery and creating replacement cells for conditions ranging from cardiovascular to Alzheimer's disease. But that promise comes with a risk: the possibility that transplanted hPSCs might also develop as unwanted tumors. In a new study published November 10, 2015 in the online journal eLIFE, researchers at University of California, San Diego School of Medicine...
https://www.biyologlar.com/novel-stem-cell-line-avoids-risk-of-introducing-transplanted-tumors -
Proteomics identifies DNA repair toolbox
During each cell division, more than 3.3 billion base pairs of genomic DNA have to be duplicated and segregated accurately to daughter cells. But what happens when the DNA template is damaged in such a way that the replication machinery gets stuck?
https://www.biyologlar.com/proteomics-identifies-dna-repair-toolbox -
Forensic botany uses plant DNA to trace crimes
Sam Houston State University is advancing the field of forensic botany with the publication of two recent studies that use marijuana DNA to link drug supplies and pollen DNA to aid in forensic investigations. In an article published in the International Journal of Legal Medicine, faculty and students from the Department of Forensic Science report that they developed a test to individualize samples of marijuana that could be used to link drugs across cases. The study examined 11 cases...
https://www.biyologlar.com/forensic-botany-uses-plant-dna-to-trace-crimes -
New GTEx findings show how DNA differences influence gene activity, disease susceptibility
Researchers funded by the National Institutes of Health Genotype-Tissue Expression (GTEx) project have created a new and much-anticipated data resource to help establish how differences in an individual's genomic make-up can affect gene activity and contribute to disease. The new resource will enable scientists to examine the underlying genomics of many different human tissues and cells at the same time, and promises to open new avenues to the study and understanding of human biology. GTEx...
https://www.biyologlar.com/new-gtex-findings-show-how-dna-differences-influence-gene-activity-disease-susceptibility -
Hacking the programs of cancer stem cells
All tumor cells are the offspring of a single, aberrant cell, but they are not all alike. Only a few retain the capacity of the original cell to create an entire tumor.
https://www.biyologlar.com/hacking-the-programs-of-cancer-stem-cells -
Researchers build molecule that could significantly reduce brain damage in stroke victims
Research teams separated by 14 hours and 9,000 miles have collaborated to advance prospective treatment for the world's second-leading cause of death. University of Nebraska-Lincoln chemists partnered with medical researchers from the National University of Singapore to develop a molecule that can inhibit an enzyme linked with the onset of stroke. Most strokes occur when a disruption of blood flow prevents oxygen and glucose from reaching brain tissue, ultimately killing neurons and other...
https://www.biyologlar.com/researchers-build-molecule-that-could-significantly-reduce-brain-damage-in-stroke-victims -
Decaying RNA molecules tell a story
Once messenger RNA (mRNA) has done its job - conveying the information to produce the proteins necessary for a cell to function - it is no longer required and is degraded. Scientists have long thought that the decay started after translation was complete and that decaying RNA molecules provided little biological information. Now a team from EMBL Heidelberg and Stanford University led by Lars Steinmetz has turned this on its head in an article published in Cell. The researchers have shown that...
https://www.biyologlar.com/decaying-rna-molecules-tell-a-story -
Perfecting a viral pack mule
Viruses aren't always bad. In fact, scientists can harness the capabilities of some viruses for good--modifying the viruses to carry drug molecules, for example. One useful virus has been cowpea mosaic virus (CPMV), a plant pathogen that can be modified to aid in tumor detection and even chemotherapy. In a new study, published online ahead of print in the journal Structure, researchers at The Scripps Research Institute (TSRI) report that, based on its structure, a hollowed-out version of CPMV...
https://www.biyologlar.com/perfecting-a-viral-pack-mule -
Spider and centipede venom evolved from insulin-like hormone
Funnel-web spider venom contains powerful neurotoxins that instantly paralyze prey (usually insects). Millions of years ago, however, this potent poison was just a hormone that helped ancestors of these spiders regulate sugar metabolism, similar to the role of insulin in humans. Surprisingly, this hormone's weaponization--described on June 11 in the journal Structure--occurred in arachnids as well as centipedes, but in different ways. Researchers at the University of Queensland in Australia...
https://www.biyologlar.com/spider-and-centipede-venom-evolved-from-insulin-like-hormone -
A microtubule 'roadway' in the retina helps provide energy for vision
Researchers have discovered a thick band of microtubules in certain neurons in the retina that they believe acts as a transport road for mitochondria that help provide energy required for visual processing. The findings appear in the July issue of The Journal of General Physiology. The retina is a layer of tissue in the back of the eye that converts light into nerve impulses. The retina contains small, specialized neurons called bipolar cells that transmit information from light-sensitive...
https://www.biyologlar.com/a-microtubule-roadway-in-the-retina-helps-provide-energy-for-vision -
Saponaria prostrata - Sabun otu, Sabun Çiçeği
Fotoğraf: Prof.Dr. Ahmet KARATAŞ
https://www.biyologlar.com/saponaria-prostrata-sabun-otu-sabun-cicegi -
Stem cell transplant from young to old can heal stomach ulcers
Bethesda, MD (June 16, 2016) -- Basic and translational research paves the way for breakthroughs that can ultimately change patient care. Three new studies from Cellular and Molecular Gastroenterology and Hepatology (CMGH) -- AGA's basic and translational open-access journal -- provide a glimpse into future treatment strategies for stomach ulcers, inflammatory bowel disease and alcoholic liver disease. Please find summaries below. To speak with the journal authors, please email...
https://www.biyologlar.com/stem-cell-transplant-from-young-to-old-can-heal-stomach-ulcers -
Hybrid cells cause chaos around cancers
Rice University researchers have built a simulation to show how cancerous tumors manipulate blood-vessel growth for their own benefit. Like all cells, those in tumors need access to the body's fine network of blood vessels to bring them oxygen and carry away waste. Tumors have learned to game the process called angiogenesis in which new vessels sprout from existing ones, like branches from a tree. But some details have been hidden until now. The ability to stop tumors through...
https://www.biyologlar.com/hybrid-cells-cause-chaos-around-cancers -
Brain scans show birds of a feather do flock together
The hottest hairstyle, the latest extreme sport, the newest viral stunt -- trends happen for a reason and now scientists have a better understanding of why. In a study using functional magnetic resonance imaging, Virginia Tech Carilion Research Institute scientists found that our inherent risk-taking preferences affect how we view and act on information from other people. The brain scans showed that study participants increased their perceived value of a gamble after seeing other people take...
https://www.biyologlar.com/brain-scans-show-birds-of-a-feather-do-flock-together -
New procedure allows long-term culturing of adult stem cells
A new procedure developed at Massachusetts General Hospital (MGH) may revolutionize the culturing of adult stem cells. In their report that has been published online prior to its appearance in the August 6 issue of Cell Stem Cell, the team describes generating and expanding airway stem cells from the sorts of tissue samples collected during routine treatment of lung disorders. The overall approach appears applicable to several other tissue types, including skin and the linings of the...
https://www.biyologlar.com/new-procedure-allows-long-term-culturing-of-adult-stem-cells -
Breakthrough in scaling up life-changing stem cell production
Scientists have discovered a new method of creating human stem cells which could solve the big problem of the large-scale production needed to fully realise the potential of these remarkable cells for understanding and treating disease.
https://www.biyologlar.com/breakthrough-in-scaling-up-life-changing-stem-cell-production -
Gene controls regeneration of injured muscle by adult stem cells
A key gene enables the repair of injured muscle throughout life. This is the finding of a study in mice led by researchers at NYU Langone Medical Center and the University of Colorado at Boulder, and published online July 21 in Cell Reports.
https://www.biyologlar.com/gene-controls-regeneration-of-injured-muscle-by-adult-stem-cells -
Embryonic gene Nanog reverses aging in adult stem cells
The images above show, from left to right, functioning stem cells, stem cells no longer functioning due to Hutchinson-Gilford Progeria syndrome (HGPS), and stem cells previously not functioning
https://www.biyologlar.com/embryonic-gene-nanog-reverses-aging-in-adult-stem-cells -
Embryonic gene Nanog reverses aging in adult stem cells
The images above show, from left to right, functioning stem cells, stem cells no longer functioning due to Hutchinson-Gilford Progeria syndrome (HGPS), and stem cells previously not functioning
https://www.biyologlar.com/embryonic-gene-nanog-reverses-aging-in-adult-stem-cells -
How a single molecule turns one immune cell into another
All it takes is one molecule to reprogram an antibody-producing B cell into a scavenging macrophage. This transformation is possible, new evidence shows, because the molecule (C/EBPa, a transcription factor) "short-circuits" the cells so that they re-express genes reserved for embryonic development. The findings appear July 30 in Stem Cell Reports, the journal of the International Society for Stem Cell Research. Over the past 28 years, researchers have shown that a number of specialized cell...
https://www.biyologlar.com/how-a-single-molecule-turns-one-immune-cell-into-another -
Legions of nanorobots target cancerous tumors with precision
The legions of nanorobotic agents are actually composed of more than 100 million flagellated bacteria
https://www.biyologlar.com/legions-of-nanorobots-target-cancerous-tumors-with-precision -
Legions of nanorobots target cancerous tumors with precision
The legions of nanorobotic agents are actually composed of more than 100 million flagellated bacteria
https://www.biyologlar.com/legions-of-nanorobots-target-cancerous-tumors-with-precision