Toplam 21 içerik listeleniyor
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Gene therapy treats all muscles in the body in muscular dystrophy dogs
Muscular dystrophy, which affects approximately 250,000 people in the U.S., occurs when damaged muscle tissue is replaced with fibrous, fatty or bony tissue and loses function. For years, scientists have searched for a way to successfully treat the most common form of the disease, Duchenne Muscular Dystrophy (DMD), which primarily affects boys. Now, a team of University of Missouri researchers have successfully treated dogs with DMD and say that human clinical trials are being planned in the...
https://www.biyologlar.com/gene-therapy-treats-all-muscles-in-the-body-in-muscular-dystrophy-dogs-haber-8760 -
Cell stress inflames the gut
Over 3.5 million people in Europe and the US suffer from Crohn's disease or ulcerative colitis – the two most common forms of IBD. Chronic bowel inflammation is caused by an overreaction of the immune system to the bacteria which naturally occur in the gut. "This overreaction can come about if, for example, the anti-stress mechanism in the cells of the intestinal mucosa does not function correctly," explains Prof. Dirk Haller of the TUM Chair of Nutrition and Immunology. What Prof. Haller is...
https://www.biyologlar.com/cell-stress-inflames-the-gut -
Stem cells + nanofibers = Promising nerve research
Every week in his clinic at the University of Michigan, neurologist Joseph Corey, M.D., Ph.D., treats patients whose nerves are dying or shrinking due to disease or injury.
https://www.biyologlar.com/stem-cells-nanofibers-promising-nerve-research -
Stem-cell approach shows promise for Duchenne muscular dystrophy
Researchers have shown that transplanting stem cells derived from normal mouse blood vessels into the hearts of mice that model the pathology associated with Duchenne muscular dystrophy (DMD) prevents the decrease in heart function associated with DMD. Their findings appear in the journal Stem Cells Translational Medicine. Duchenne muscular dystrophy is a genetic disorder caused by a mutation in the gene for dystrophin, a protein that anchors muscle cells in place when they contract. Without...
https://www.biyologlar.com/stem-cell-approach-shows-promise-for-duchenne-muscular-dystrophy -
Stem cell breakthrough could set up future transplant therapies
A new method for creating stem cells for the human liver and pancreas, which could enable both cell types to be grown in sufficient quantities for clinical use, has been developed by scientists. Using the technique, researchers have for the first time been able to grow a pure, self-renewing population of stem cells specific to the human foregut, the upper section of the human digestive system. These so-called "Foregut stem cells" could then be developed further to produce liver or pancreatic...
https://www.biyologlar.com/stem-cell-breakthrough-could-set-up-future-transplant-therapies -
Damaged DNA may stall patrolling molecule to initiate repair
Sites where DNA is damaged may cause a molecule that slides along the DNA strand to scan for damage to slow on its patrol, delaying it long enough to recognize and initiate repair. The finding suggests that the delay itself may be the key that allows the protein molecule to find its target, according to researchers at the University of Illinois at Chicago. Usually, the repair protein zips along quickly, says Anjum Ansari, UIC professor of physics and co-principal investigator on the study,...
https://www.biyologlar.com/damaged-dna-may-stall-patrolling-molecule-to-initiate-repair -
Stem cells might heal damaged lungs
Collectively, such diseases of the airways as emphysema, bronchitis, asthma and cystic fibrosis are the second leading cause of death worldwide.
https://www.biyologlar.com/stem-cells-might-heal-damaged-lungs -
Great Barrier Reef marine reserves combat coral disease
A new and significant role for marine reserves on the Great Barrier Reef has been revealed, with researchers finding the reserves reduce the prevalence of coral diseases. It's been known for some time that marine reserves are important for maintaining and enhancing fish stocks, but this is the first time marine reserves have been shown to enhance coral health on the Great Barrier Reef. Researchers from the ARC Centre of Excellence for Coral Reef Studies at James Cook University found that...
https://www.biyologlar.com/great-barrier-reef-marine-reserves-combat-coral-disease -
Proteomics identifies DNA repair toolbox
During each cell division, more than 3.3 billion base pairs of genomic DNA have to be duplicated and segregated accurately to daughter cells. But what happens when the DNA template is damaged in such a way that the replication machinery gets stuck?
https://www.biyologlar.com/proteomics-identifies-dna-repair-toolbox -
Gene controls regeneration of injured muscle by adult stem cells
A key gene enables the repair of injured muscle throughout life. This is the finding of a study in mice led by researchers at NYU Langone Medical Center and the University of Colorado at Boulder, and published online July 21 in Cell Reports.
https://www.biyologlar.com/gene-controls-regeneration-of-injured-muscle-by-adult-stem-cells -
DNA research offers clues on cell mutation
A team of researchers from Colorado State University has been studying DNA damage in living cells to learn more about how genetic abnormalities arise. It has long been known that DNA molecules in every cell get constantly damaged by things from the outside environment, like sunlight, cigarette smoke and radiation. However, more recently researchers have discovered that sources from within the cell itself can sometimes be even more damaging. DNA, or deoxyribonucleic acid, is found in the...
https://www.biyologlar.com/dna-research-offers-clues-on-cell-mutation -
DNA research offers clues on cell mutation
A team of researchers from Colorado State University has been studying DNA damage in living cells to learn more about how genetic abnormalities arise. It has long been known that DNA molecules in every cell get constantly damaged by things from the outside environment, like sunlight, cigarette smoke and radiation. However, more recently researchers have discovered that sources from within the cell itself can sometimes be even more damaging. DNA, or deoxyribonucleic acid, is found in the...
https://www.biyologlar.com/dna-research-offers-clues-on-cell-mutation -
Scientists discover protein's starring role in genome stability, and possibly cancer prevention
If you have a soft spot for unsung heroes, you'll love a DNA repair protein called XPG. Scientists from the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) discovered that XPG plays a previously unknown and critical role helping to maintain genome stability in human cells. Their findings also raise the possibility that the protein helps prevent breast, ovarian, and other cancers associated with defective BRCA genes. The research, which is published online Jan....
https://www.biyologlar.com/scientists-discover-proteins-starring-role-in-genome-stability-and-possibly-cancer-prevention -
New DNA research reveals genetic heritage of elusive vaquita
A new method of teasing information from scarce and highly degraded genetic samples is helping NOAA Fisheries and Mexican scientists unravel the genetic heritage of the enigmatic vaquita, the most endangered marine mammal on Earth. Genetic studies are important to the international effort to conserve the vaquita because the DNA that holds their genetic code can unlock the secrets of how they came to be. For instance, it can reveal the story of how - and how long ago - the animals evolved into...
https://www.biyologlar.com/new-dna-research-reveals-genetic-heritage-of-elusive-vaquita -
New DNA research reveals genetic heritage of elusive vaquita
A new method of teasing information from scarce and highly degraded genetic samples is helping NOAA Fisheries and Mexican scientists unravel the genetic heritage of the enigmatic vaquita, the most endangered marine mammal on Earth. Genetic studies are important to the international effort to conserve the vaquita because the DNA that holds their genetic code can unlock the secrets of how they came to be. For instance, it can reveal the story of how - and how long ago - the animals evolved into...
https://www.biyologlar.com/new-dna-research-reveals-genetic-heritage-of-elusive-vaquita -
May repairs full of mistakes develop into cancer?
These are DNA double-strand breaks, introduced by ionizing radiation or other mechanisms, are repaired rapidly and precisely in normal cells (right pathway). In contrast, compromised Tel1 activation with inefficient end...
https://www.biyologlar.com/may-repairs-full-of-mistakes-develop-into-cancer -
May repairs full of mistakes develop into cancer?
These are DNA double-strand breaks, introduced by ionizing radiation or other mechanisms, are repaired rapidly and precisely in normal cells (right pathway). In contrast, compromised Tel1 activation with inefficient end...
https://www.biyologlar.com/may-repairs-full-of-mistakes-develop-into-cancer -
Ökaryotlarda Homolog rekombinasyon
Homolog rekombinasyonun olması çoğu ökaryotik hücrede mitoz ve mayoz için esastır. Mitoz sırasında homolog rekombinasyon, iyonlaştırıcı radyasyon veya DNA'ya hasar verici kimyasalların neden olduğu çift iplikli kırıkları tamir etmeye yarar.[21] Bunların tamir edilmemesi durumda somatik hücrelerde kromozom parçaları arasında büyük ölçekli yer değişimlerine (rearrangement) yol açar,[22] bu da kansere neden olabilir. Mayozda homolog rekombinasyon, profaz I...
https://www.biyologlar.com/okaryotlarda-homolog-rekombinasyon -
Hasar Gören Sinir Hücreleri Taşınabilir Mitokondrilerle Onarılacak
Rockefeller Üniversitesi’nden bir grup araştırmacı, mitokondrilerin nöronal aksonlardaki taşınımı yükseltildiği takdirde, farelerin sinir hücelerinin yaralanma sonrası onarım becerilerinde artış olduğunu saptadı.
https://www.biyologlar.com/hasar-goren-sinir-hucreleri-tasinabilir-mitokondrilerle-onarilacak -
Sibernetik İmplantlar Beyin Hasarını Onarabiliyor
Beyin hasarını onaran sibernetik implantları temsili bir resim.
https://www.biyologlar.com/sibernetik-implantlar-beyin-hasarini-onarabiliyor -
Telogen Kök Hücreleri Hasarlı Nöronları Onarabiliyor
Saç kökleri veya kıl kökleri olarak andığımız foliküllerdeki kök hücrelerin, farelerde; nöronları çevreleyen gliaların rejenerasyonunu sağlamada oldukça büyük bir potansiyele sahip olduğu gösterildi. Görsel Telif: Sandeep Joshi, University of Maryland School of Medicine
https://www.biyologlar.com/telogen-kok-hucreleri-hasarli-noronlari-onarabiliyor